The four main precursors used to manufacture mdma are. Synthesis of essential drugs describes methods of synthesis, activity and implementation of diversity of all drug types and classes. This formula is exemplified for mda 3,4methylenedioxy phenylisopropylamine. These services help to submit any pdf or word file without printing them out. Here we report the successful synthesis of mdma from piperine extracted. In short the mdma oil can be an oil or an salt, the salt is water. It produces feelings of increased energy, euphoria, emotional. Mdma ecstasy is a synthetic amphetamine which produced both stimulantlike and hallucinogenlike effects in humans. Mdp2p was prepared by two different synthesis methods, i.
However, people with less than 2 years of college chemistry experience would probably not be capable of sucessfully synthesizing mdma, and would either botch. Test with ph paper every 5 drops or so keep adding the muriatic acid until the ph of the solution is 56 or just. This synth is slightly outdated and youre not going to help your friend unless you have some post secondary organic chemistry and lab experience under your belt, reading a textbook will not prepare you for exothermic reactions or setting up a vacuum distill. Mda lacks the wonderful empathogenic qualities that makes mdma so special. Bright stars mdma synthesis for the first time chemist. This file contains additional information such as exif metadata which may have been added by the digital camera, scanner, or software program used to create or digitize it. Mdma is manufactured by safrole, a liquid extract from sassafras trees. With mdma it brings out the psychedelic qualities beautifully, but id definitely wait til well after the peak, and go easy on the 2cb you dont need much to blast off, and it lasts for ages a very visual combination, and some strange physical effects. The synthesis of mdp2p from isosafrole will require the use of a vacuum pump to evaporate the solvent from the final product in vacuo. Reductive amination of ketones using pdc and formic acid pdf synthesis of. A complete mdma synthesis for the first time chemist 3. With over 2300 references, mainly patent, for the methods of synthesis for over 700 drugs, along with the most widespread synonyms for these drugs, this book fills the gap that exists in the literature of drug synthesis.
A complete mdma synthesis for the first time chemist compilation and. Aug 01, 2007 pour it into the flask that contains the mdma oil, and drop the stirbar in too. So youve woken up in the middle of the night, your mind entranced by a singular glorious thought. A complete mdma synthesis for the first time chemist hip forums. Non of the herein shown pictures is taken by the producer of this book and thus the producer can not be held responsible for this syntheses seen on the pictures. Animal studies show that mdma may also damage specific neurons in the brain, but research on mdmas effects on the human brain is not conclusive at. Synthesis of mdma mdma is a semisynthetic compound which can be made relatively easily from available precursors. Request pdf determination of synthesis method of ecstasy based on the basic impurities mdma was prepared by five different synthesis routes, i. A complete mdma synthesis for the first time chemist doc.
Mdma is mainly ingested orally in tablets 50150 mg. Mdma is a synthetic, psychoactive drug that can induce a state of euphoria, stimulation, as well as distortions in time and perception, in addition to an enhanced enjoyment from tactile experiences. The synthesis and characterisation of mdma derived from a catalytic oxidation of material isolated from black pepper reveals potential route specific impurities. Structural biochemistrymdma wikibooks, open books for an. We now turn our attention to the synthesis for ecstacy of which there are several choices.
Other methods of abuse are crushing and snorting or injecting. Synthetic studies and pharmacological evaluations on the. Its exactly the same effects as mdma, but its methylenedioxymethcathinone instead of methylenedioxymethamphetamine. It has been described as a stoning intoxication with a full dose. First of all i m going to tell you if you would want to make mdma you would. The manual recommended by many illicit chemists is this. This book is only to be used for informational purposes, and all the info herein is gathered on the internet. In popular culture, mdma has become widely known as ecstasy, usually referring to its street pill form, although this term may also include the presence of possible adulterants. Chemical synthesis of mdma 3,4methylenedioxynmethylamphetamine. Pour it into the flask that contains the mdma oil, and drop the stirbar in too. This is everything you need for making p2np, from left to right. Scribd is the worlds largest social reading and publishing site.
See all 2 formats and editions hide other formats and editions. Swim has been doing some ab extractions with some of his favorite. Although first patented by merck in 1912 as a precursor to a new pharmaceutical, the pharmacological effects were not studied until fifteen years later whilst the recreational use of mdma remained relatively unknown until the early 1980s. Pmk glycidate the starting material for the currently most popular method has a bias. Pdf the synthesis and characterisation of mdma derived from. Acetylation of the 3hydroxy phenolic group of morphine which leads to. Mdma, its synthesis and most of its precursors are illegal in most parts of the world. The appearance of smoke rings as visual hallucinations has been ascribed to this drug. During mdma synthesis by leuckart method as well as safrole bromination the compound 12 is produced. Yes, mdma is generally illegal to make, have, or sell. Hi everyone, lately ive been considering mixing 2cb and mdma together.
The original mdma synthesis described in mercks patent involves brominating safrole to,4methylenedioxyphenyl2bromopropane and then reacting this adduct with methylamine. Mdma and ghb, two common club drugs teter and guthrie concentration c max after oral ingestion appears to be dose dependent. This occurs by physical and chemical manipulations usually involving one or more reactions. The synthesis and characterisation of mdma derived from a. Mdma 3,4methylenedioxynmethylamphetamine is a synthetic amphetamine derivative that has both stimulant and hallucinogenic properties. Test with ph paper every 5 drops or so keep adding the muriatic acid until the ph of the solution is 56 or just barely acidic. Otherwise, mdma can be synthesized from piperonal, isosafrole, or safrole. Determination of synthesis method of ecstasy based on the basic. Pmk, f 3,4methylenedioxyphenyl2nitropropene, g mdma figure 2. The only difference is that it doesnt inhibit the reuptake of seritonin as much as dopamine, whereas mdma equally affects the seritonin and dopamine. Synthesis and impurity profiling of mdma prepared from commonly available starting materials article in forensic science international 223 november 2012 with 7,315 reads how we measure reads.
The primary precursor chemicals are produced in india, china, poland, germany, and increasingly elsewhere. Mdma was prepared by five different synthesis routes, i. It was synthesized in 1912 by merck pharmaceuticals and patented in 1914. A complete mdma synthesis for the first time chemist. Saying you plan on synthesizing mdma and doing it are two different things. National institute on drug abuse nida mdma ecstasy abuse. The synthesis itself can be performed in a series of weekends or in a straight shot. The classic ketone approach certainly not the only possibility, but the best documented one has a lot of variations, but the basic scheme is the oxidation of the plant oil safrole 1allyl3,4methylenedioxybenzene into a ketone 3,4methylenedioxyphenyl2propanone, which is then condensed with methylamine and reduced to the final.
Mdma can cause a dangerous increase in body temperature that can be fatal in some environments. Clinical studies suggest that mdma may increase the risk of longterm, perhaps permanent, problems with memory and learning. Mdma september 20 page 1 mdma ecstasy or molly mdma 3,4methylenedioxymethamphetamine, popularly known as ecstasy or, more recently, as molly, is a synthetic, psychoactive drug that has similarities to both the stimulant amphetamine and the hallucinogen mescaline. Ok i just found this file a few days ago and i wanted to post it as to let the chemists look at it and tell me what they think. Neither for the writing of this book, since everything is learned right of internet.
Its cool from a chemistry standpoint, but you wont be making mdma with this unless you figure out a black market source for safrole. Mdma can also stress the heart, increasing heart rate and blood pressure, and can damage the kidneys. The forum was started in 1997 by strike and attracted a vibrant international community of more than 8,500 active users until it went offline by the end of 2004 at about half a million posts. Safrole, extracted in the form of sassafas oil through a process known as fractional distillation, is a naturally occurring genotoxic. After some tryouts swim and friends came up with 10 mg 2cb and 100 mg mdma per tablet. Safrole is very much controlled nowadays and i wouldnt be surprised if other reagents in this synthesis are watched as well. In modern laboratory uses, the process is reproducible, reliable, and established to work the same in multiple laboratories a chemical synthesis involves one or more compounds known as.
Ive seen 2cb described as psychic tofu, but ime its more like a psychic amp, taking whatever youve ingested and turning it up to 11. The traditional precursor pmk, also called mdp2p doesnt come in isomers. The reason why i post it is that this has to be one of the easier mdma synthesis that i have seen, it requires readily available chemicals such as h2o2, formic. Swim has been looking into synthesizing mdma for a little while now but was lacking in skill still am but swim is getting better. The expertise needed in mdma production varies according to the route of synthesis. Non of the herein shown pictures is taken by the producer of this book and thus the producer can not be held responsible for this syntheses. However, safrole is now rather hard to get hold of, precisely because it. Information from its description page there is shown below. The chemistry of methylenedioxyphenethylamine mdma. Mdma was synthesized in 1912 by the german pharmaceutical company merck kgaa darmstadt, germany as part of a program to identify new hemostatic bloodclotting agents. Mdma was made fully illegal in the united states in 1977 and was formerly used as an antidepressant and antianxiety medicine. A glass eyedropper three small glass bottles with lids approx.
As a result, mdma is more or less illegal in most possibly all countries. Chemical properties and mechanism of action for mdma. This is not the best synthesis in terms of conditions, or yield, but its by far the simplest. Also, you will never find or synth 100% pure molly, if anyone says that have 100% pure mdma they are lieing. The drug mdma has been around since the early 1900s and was first synthesised by chemist anton kollisch. Anorexia and pupil dilation accompany mda as with other psychedelics and overall it is a pleasant trip. A complete mdma synthesis for the first time chemist kindle edition by dean stone author format. If you do not have exceptional chemistry experience and lack an appropriate approval from the respective drug enforcement agency in your country, do not follow and apply the methods as outlined here. Part of its success was its ambitious crew of moderators and its unique mix of topics. Mda is slightly more simple to make than mdma and still quite rewarding. Dec 18, 2004 swim likes 2cb, its a dose depending multilevel psychedelic. Mdma 3,4methylenedioxynmethamphetamine, chemical formula of c 11 h 15 n o 2 and molecular mass of 193.
Pdf the synthesis and characterisation of mdma derived. The hive was an influential web forum discussing the chemistry of mindaltering compounds. To a cooled mixture of 34 g 30% h2o2 and 150 g formic acid, add dropwise a solution of 32. Psilocin analogs, bromine or formyl substituted at either the 5 or 7position pdf psilocin synthesis through pdcatalyzed alkyne cyclization pdf largescale synthesis of psilocin and psilocybin pdf extraction and analysis of indole derivatives from fungal biomass. The reaction of heroin synthesis in the presence of acetic anhydride as the acetylating agent can be schematically presented as shown in fig. Buy a complete mdma synthesis for the first time chemist. Merck patent for synthesizing methylhydrastinine from. Rhodium shut down several years ago, so a lot of the info is outdated. The reaction goes from morphine trough 3acetylmorphine to 3,6diacetylmorphineheroin 7 and references herein. Chemical synthesis is the artificial execution of useful chemical reactions to obtain one or several products.
Mdma essentially acts as a releasing agent of serotonin, norepinephrine, and dopamine all of which are naturally occurring neurotransmitters. Once amalgamation was complete the h2o was decanted and the. First, a complete grocery list for mdma precursors is pretty suspicious, and. The new pathway was patented in order to evade an existing patent by a local competitor. We now turn our attention to the synthesis for ecstacy of. Mdma history the drug mdma ecstasy, e is a ringsubstituted amphetamine analog commonly taken as a recreational drug of abuse. The german patent for mercks synthesis of mdma methylsafrylamin. Synthesis instructions exist which can be followed by an amateur with very little knowledge of chemistry. Clandestine production is easiest starting with pmk.
Synthetic studies and pharmacological evaluations on the mdma. Manufacturing process of ecstasy mdma mdma 3,4methylenedioxynmethylamphetamine is an entactogenic drug of the phenethylamine and amphetamine class of drugs. However, safrole is now rather hard to get hold of, precisely because it is so easy to synth mdma from it. In case of leuckart method compound 12 arise in reaction of mdp2p impurity,4methylenedioxyphenyl1propanone, and methylamine fig. The patent for the once legal drug was approved on christmas of 1912. Synthesis and impurity profiling of mdma prepared from. Determination of synthesis method of ecstasy based on the. Stir so that the whole thing is mixed up real well now drip in muriatic acid slowly. The complete birch by mr clean birch reduction of pseudoephedrine to. Recent data shows that 6% and 4% of 12 th grade students had used ecstasy in their lifetime and in the past year respectively. A complete mdma synthesis for the first time chemist 3 hip. Mdma abusers usually take mdma by stacking taking two or more. A complete mdma synthesis for the first time chemist hip.566 1039 1357 127 1282 1030 991 1507 1557 410 1061 308 344 630 756 563 1497 521 1067 165 908 714 758 228 1065 1367 25 993 1234 1533 792 277 806 1121 1437 354 235 254 908 538 435 478 198 829